Dr Kaska Koltowska
Postdoctoral Researcher | Hogan Lab
Genomics Of Development and Disease, Institute for Molecular Bioscience, the University of Queensland
Lymphatic Education & Research Network Post-doctoral Fellow
Kaska graduated with a BSc in Molecular Genetics from King’s College London in 2007. She continued her education at the University College London by conducting a PhD in Developmental Biology in Elke Ober’s laboratory at the National Institute for Medical Research at Mill Hill, which she completed in 2011. Kaska's PhD research led her to discover an essential gene for regulating organ growth during development. To continue pursuing her interest in understanding how fully functional organs are formed within an embryo, she moved to the Institute for Molecular Bioscience at the University of Queensland to work as a Post-doctoral Researcher in Ben Hogan’s laboratory. Currently her work focuses on dissecting the molecular cues key to lymphatic system formation.
The main focus of my post-doctoral research is to dissect the molecular and cellular processes critical to establishing lymphatic vessel identity. My current work focuses on teasing out the early events that regulate the specification of lymphatic vasculature in zebrafish. By utilising zebrafish mutants for transcription factors combined with time-lapse live imaging I am investigating these transcriptional modulators in conjunction with the cellular processes that drive the accusation of lymphatic identity from a pre-excisting venous fate.
Phone: +61 7 3346 2062
Phone: +61 7 3346 2341
With the Hogan lab since 2011.
Bower NI, Koltowska K, Pichol-Thievend C, Virshup I, Paterson S, Lagendijk AK, Wang W, Lindsey BW, Bent SJ, Baek S, Rondon-Galeano M, Hurley DG, Mochizuki N, Simons C, Francois M, Wells CA, Kaslin J, Hogan BM. Mural lymphatic endothelial cells regulate meningeal angiogenesis in the zebrafish. Nature Neuroscience 2017 May 1. In press. Pubmed
Koltowska K*, Lagendijk AK*, Pichol-Thievend C, Fischer JC, Francois M, Ober EA, Yap AS, Hogan BM. Vegfc Regulates Bipotential Precursor Division and Prox1 Expression to Promote Lymphatic Identity in Zebrafish. Cell Reports 2015 Dec 1; 13(9): 1828–1841. *Co-first authors. Journal cover art
Koltowska K, Paterson S, Bower NI, Baillie GJ, Lagendijk AK, Astin JW, Chen H, Francois M, Crosier PS, Taft RJ, Simons C, Smith KA, Hogan BM. mafba is a downstream transcriptional effector of Vegfc signaling essential for embryonic lymphangiogenesis in zebrafish. Genes & Development 2015 Aug 1;29(15):1618-30. Journal cover art
Koltowska et al 2015
Le Guen L, Karpanen T, Schulte D, Harris N, Koltowska K, Roukens G, Bower NI, Van Impel A, Stacker SA, Achen MG, Schulte-Merker S, Hogan BM. Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis. Development. 2014 Mar; 141(6):1239-49.
Kartopawiro J, Bower NI, Karnezis T, Kazenwadel J, Betterman KL, Lesieur E, Koltowska K, Astin J, Crosier P, Vermeren S, Achen MG, Stacker SA, Smith KA, Harvey NL, Francois M, Hogan BM. Arap3 is dysregulated in a mouse model of hypotrichosis- lymphedema-telangiectasia and regulates lymphatic vascular development. Human Molecular Genetics 2014 Mar 1; 23(5):1286-97.
Duong T, Koltowska K, Pichol-Thievend C, Le Guen L, Fontaine F, Smith KA, Truong V, Skoczylas R, Stacker SA, Achen MG, Koopman P, Hogan BM*, Francois M* VEGFD regulates blood vascular development by modulating SOX18 activity. Blood. 2014 Feb; 123(7):1102-12. (*Equal last author) Journal Cover Art
Koltowska K, Betterman KL, Harvey NL, Hogan BM. Getting out and about: the emergence and morphogenesis of the vertebrate lymphatic vasculature. Development. 2013 May; 140(9):1857-70. Invited Review
Other Selected Publications
Koltowska K, Apitz H, Stamataki D, Hirst EM, Verkade H, Salecker I, Ober EA. Ssrp1a controls organogenesis by promoting cell cycle progression and RNA synthesis. Development. 2013 May;140(9):1912-8.
Wood AJ, Schulz R, Woodfine K, Koltowska K, Beechey CV, Peters J, Bourc'his D, Oakey RJ. Regulation of alternative polyadenylation by genomic imprinting. Genes Dev. 2008 May 1;22(9):1141-6.