Dr Neil Bower
Postdoctoral Researcher | Hogan Lab
Genomics Of Development and Disease, Institute for Molecular Bioscience, the University of Queensland
After completing his PhD at The University of Queensland and CSIRO in 2006, Neil moved to The Scottish Ocean Institute at The University of St Andrews, UK where he examined the role of IGF signalling in muscle development and performed a large scale genomic analysis to identify novel genes involved in muscle growth (BBSRC and MAST funded fellowships).
In his current position at the IMB, Neil works as a Research officer in the Hogan laboratory where he is interested in the use of genome editing technologies such as TALENs and CRISPRs to understand the vascular system with vascular disorders as a biological focus.
Phone: +61 7 3346 2062
Phone: +61 7 3346 2341
UQ Researchers: Dr Neil Bower
With the Hogan lab since 2011
Discoveries in the media
Neil Bower and researchers from the Hogan lab led by Ben Hogan have discovered a new type of lymphatic brain cell in zebrafish, described in humans as 'mato' or lipid laden cells, which clear fats and lipids from the brain. The discovery, a collaboration with researchers from The University of Melbourne, Monash Univeristy and Japan's National Cerebral and Cardiovascular Centre was published in Nature Neuroscience on 1st May.
The discovery was featured on the Nature Neuroscience cover: major arteries (yellow), surrounded by mural lymphatic endothelial cells (magenta), enter the zebrafish brain ventrally (nuclei are in cyan), while networks of finer blood capillaries permeate the deeper tissue in this cross-section composite image.
The discovery was featured on 7 international scientific and medical news sites including EurekAlert!, MedicalXpress, Fierce Biotech, Science Newsline, The Medical News, Medical News Today, The University of Queensland and the scientific blogs Neuroscience News and Brain Blogger.
UQ Press Release 2 May 2017 Scientists surprised to discover lymphatic 'scavenger' brain cells
The discovery that Vegfd modulates both angiogenesis and lymphangiogenesis during zebrafish embryonic development was featured on the cover of Development. The cover image shows a confocal projection (pseudocoloured yellow) of the blood vasculature of a 72 hpf Tg(fli1a:egfp) zebrafish embryo injected with flt1 morpholino. Flt1 suppresses Vegfd and Vegfc signalling, which drives hyperbranching in developing intersegmental arteries. See Research article by Bower et al. on p. 507.
Bower NI, Koltowska K, Pichol-Thievend C, Virshup I, Paterson S, Lagendijk AK, Wang W, Lindsey BW, Bent SJ, Baek S, Rondon-Galeano M, Hurley DG, Mochizuki N, Simons C, Francois M, Wells CA, Kaslin J, Hogan BM. Mural lymphatic endothelial cells regulate meningeal angiogenesis in the zebrafish. Nature Neuroscience 2017 Jun;20(6):774-783. Cover art Pubmed
De Angelis JE*, Lagendijk AK*, Chen H, Tromp A, Bower NI, Tunny KA, Brooks AJ, Bakkers J, Francois M, Yap AS, Wicking C, Hogan BM#, Smith KA#. Tmem2 regulates embryonic Vegf-signaling by controlling Hyaluronic acid turnover. Developmental Cell 2017. Jan 23 Volume 40, Issue 2, p123–136. *Joint first authors #Joint senior authors. Pubmed
Bower NI, Vogrin A, Le Guen L, Chen J, Stacker SA, Achen MG, Hogan BM. Vegfd modulates both angiogenesis and lymphangiogenesis during zebrafish embryonic development. Development 2017 Jan 13;144:507-518. Cover art Pubmed
Capon SJ, Baillie GJ, Bower NI, da Silva JA, Paterson S, Hogan BM, Simons C, Smith KA. Utilising polymorphisms to achieve allele-specific genome editing in zebrafish. Biology Open 2017 Jan 15;6(1):125-131. Pubmed
Crawford J, Bower NI, Hogan BM, Taft RJ, Gabbett MT, McGaughran J, Simons C. Expanding the genotypic spectrum of mutations in Hennekam syndrome. Am J Med Genet A 2016 Oct;170(10):2694-7. Pubmed
Koenig AL, Baltrunaite K, Bower NI, Rossi A, Stainier DY, Hogan BM, Sumanas S. Vegfa signaling promotes zebrafish intestinal vasculature development through endothelial cell migration from the posterior cardinal vein. Developmental Biology 2016 Mar 1; 411(1):115-27. Pubmed
Koltowska K, Paterson S, Bower NI, Baillie GJ, Lagendijk AK, Astin JW, Chen H, Francois M, Crosier PS, Taft RJ, Simons C, Smith KA, Hogan BM. mafba is a downstream transcriptional effector of Vegfc signaling essential for embryonic lymphangiogenesis in zebrafish. Genes & Development 2015 Aug 1;29(15):1618-30. Cover art
Jeffery J, Neyt C, Moore W, Paterson S, Bower NI, Chenevix-Trench G, Verkade H, Hogan BM, Khanna KK. Cep55 regulates embryonic growth and development by promoting Akt stability in zebrafish. The FASEB Journal 2015 May; 29(5): 1999-2009. Pubmed
Chang GH, Lay AJ, Ting KK, Zhao Y, Coleman PR, Powter EE, Formaz-Preston A, Jolly CJ, Bower NI, Hogan BM, Rinkwitz S, Becker TS, Vadas MA, Gamble JR. ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions. Small GTPases. 2014 Jul; 5(3):1-15.
Coxam B, Sabine A, Bower NI, Smith KA, Skoczylas R, Astin J, Crosier P, Parton R, Harvey N, Petrova T, Schulte-Merker S, Francois M, Hogan BM. Pkd1 regulates lymphatic vascular morphogenesis during development. Cell Reports. 2014. 2014 May 8; 7(3):623-33.
Le Guen L, Karpanen T, Schulte D, Harris N, Koltowska K, Roukens G, Bower NI, Van Impel A, Stacker SA, Achen MG, Schulte-Merker S, Hogan BM. Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis. Development. 2014 Mar; 141(6):1239-49.
Kartopawiro J, Bower NI, Karnezis T, Kazenwadel J, Betterman KL, Lesieur E, Koltowska K, Astin J, Crosier P, Vermeren S, Achen MG, Stacker SA, Smith KA, Harvey NL, Francois M, Hogan BM. Arap3 is dysregulated in a mouse model of hypotrichosis- lymphedema-telangiectasia and regulates lymphatic vascular development. Human Molecular Genetics 2014 Mar 1; 23(5):1286-97.
Macheda ML, Sun WW, Kugathasan K, Hogan BM, Bower NI, Halford MM, Zhang YF, Jacques BE, Lieschke GJ, Dabdoub A, Stacker SA. The Wnt Receptor Ryk Plays a Role in Mammalian Planar cell Polarity Signaling. J Biol Chem. 2012 Aug; 287(35)29312-23.
Additional Key Publications
Bower NI, Garcia de la Serrana D, Cole NJ, Hollway GE, Lee HT, Assinder S, Johnston IA. STAC3 is required for myotube formation and myogenic differentiation in vertebrate skeletal muscle. Journal of Biological Chemistry. 2012; 287(52):43936-49. doi: 10.1074/jbc.M112.361311.
Bower NI and Johnston IA. Discovery and characterisation of nutritionally-regulated genes associated with muscle growth in Atlantic salmon. Physiological Genomics 2010; Epub PMID: 20663983.
Bower NI and Johnston IA. Transcriptional regulation of the IGF signaling pathway by amino acids and insulin-like growth factors during myogenesis in Atlantic salmon. PLoS ONE 2010; 5(6): e11100. doi:10.1371/journal.pone.0011100
Bower NI, and Johnston IA. Paralogues of Atlantic salmon myoblast determination factor genes are distinctly regulated in proliferating and differentiating myogenic cells. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 2010; 298: R1615-R1626, 2010.
Bower NI, Li X, Taylor R, Johnston IA. Switching-on to fast growth: The insulin-like growth factor system in Atlantic salmon fast muscle. Journal of Experimental Biology 2008; 211:3859-3879
Reviews, Commentaries and Book Chapters
Johnston IA, Bower NI and Macqueen DJ. Growth and the regulation of myotomal muscle mass in teleost fish. Journal of Experimental Biology 2011; doi: 10.1242/jeb.038620