Centre news
keep up to date on our discoveries, publications and awards

cardiovascular biology blog

Improved methods for generating blood vessel and heart cells from hPSCs

img

Improved methods for generating blood vessel and heart cells from hPSCs

Dr Nathan Palpant and Clayton Friedman from UQ CCVBs Stem Cells and Cardiovascular Development Laboratory and their collaborators from the University of Washington School of Medicine in the USA, have developed an efficient protocol to differentiate human pluripotent stem cells into heart muscle cells (cardiomyocytes) and blood vessel cells (endothelium).
 
The method has been published in Nature Protocols (Vol 12 No 1, 2017).
 
The new and improved protocol yields differentiation efficiencies exceeding those of previous protocols and is the first to provide a common platform for the differentiation of cardiomyocytes and endothelial cell subtypes from hPSCs.
 
Heart disease remains the single biggest killer of Australians. The generation of cardiovascular cell types is a critical step towards understanding the basis of cardiovascular disease (CVD). These cells have the potential to provide critical therapies for the treatment of CVD.

Learn more about the Palpant Lab
 
Read the abstract via PubMed
 
Dowload the article via Nature Protocols