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Researchers grow beating human heart cells

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Researchers grow beating human heart cells

Nathan Palpant and colleagues at the Institute for Stem Cell and Regenerative Medicine in Seattle, USA have grown beating human heart cells from stem cells. Published in the latest issue of Development, the study discovered the optimal conditions required for growth of the three different cell types that form the heart, blood and blood vessels. The breakthrough is another step forward in the field of bioengineering heart tissue for the development of novel therapeutics to treat cardiovascular disease. An image of the engineered cells forming microvessels in a microfluidics chamber appears on the September cover of the journal.

Palpant NJ1*, Pabon L1, Roberts M, Hadland B, Jones D, Jones C, Moon R, Ruzzo W, Bernstein I, Zheng Y, Murry CE. Inhibition of β-catenin signaling re-specifies anterior-like endothelium into beating human cardiomyocytes. Development 2015 Sep 15;142(18):3198-209. 1Equal first authors

*This study was performed when Nathan Palpant was at the Department of Pathology, the Centre for Cardiovascular Biology, and the Institute for Stem Cell and Regenerative Medicine, at the University of Washington School of Medicine, Seattle, USA.
The Palpant Lab will be opening within the Institute for Molecular Bioscience at The University of Queensland in November of 2015.

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